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The problem? Lots of chemicals are in our environment. Some are neutral, some bad, many undetermined. Some are put there by human activity, others occur naturally. We (humans) and other living things are constantly exposed to these chemicals, sometimes at low, consistent levels, sometimes at high, acute levels. However, regardless of how the chemicals arrived, there are MANY in the environment - and we're exposed to them simultaneously.
My research attempts to tackle questions of how these chemical mixtures differ in their effects from single chemical exposures. I'm particularly interested in waterborne exposures of a variety of chemical classes and their effects on the cardiovascular and endocrine systems. I predominantly use in vitro (cell culture) models in my research as non-animal alternatives, although some work uses zebrafish.
I am currently a Ph.D. candidate in Pharmacology (concentration: Molecular and Environmental Toxicology) at Wayne State University School of Medicine. I'm conducting my dissertation in the laboratory of Dr. Chris Kassotis, an expert on environmental endocrine disruptive mixtures and in vitro models for cardiometabolic disease.
My research attempts to tackle questions of how these chemical mixtures differ in their effects from single chemical exposures. I'm particularly interested in waterborne exposures of a variety of chemical classes and their effects on the cardiovascular and endocrine systems. I predominantly use in vitro (cell culture) models in my research as non-animal alternatives, although some work uses zebrafish.
I am currently a Ph.D. candidate in Pharmacology (concentration: Molecular and Environmental Toxicology) at Wayne State University School of Medicine. I'm conducting my dissertation in the laboratory of Dr. Chris Kassotis, an expert on environmental endocrine disruptive mixtures and in vitro models for cardiometabolic disease.
Publications
In vitro endocrine and cardiometabolic toxicity associated with artificial turf materials
Kyle R. Siegel, Brooklynn R. Murray, Jeff Gerhart, Christopher D. Kassotis
Environmental Toxicology and Pharmacology, vol. 111, 2024
Kyle R Siegel, Roxanne Bérubé, Matthew Day, Samantha Heldman, Coreen Daley, Brooklynn R Murray, Rachelle Hecht, Élyse Caron-Beaudoin, and Christopher D Kassotis
Reproduction, 2024
Kyle R. Siegel, Muskanjot Kaur, A. C. Grigal, R. Metzler, G. Dickinson
Ecology and Evolution, 2022
Jessica A. Nardone, Shrey Patel, Kyle R. Siegel, Dana Tedesco, C. McNicholl, J. O’Malley, J. Herrick, R. Metzler, B. Orihuela, D. Rittschof, G. Dickinson
Front. Mar. Sci., 2018